Chelsea manager Antonio Conte confirmed in October that the Blues had pursued the 29 year old before he signed a new four year contract in the summer, but the situation has changed dramatically in the last few weeks.
Naniggolan was disciplined for posting a video himself smoking and drinking, and was left out of the side for Roma’s 2-1 home defeat to Atalanta last week.
The Belgian midfield enforcer was set to be reintegrated into the squad according to reports, but Guangzhou have used the opportunity to offer €50m (£44.5m) for the player.
The Chinese side are managed by Fabio Cannavaro, and the Italian has reportedly already discussed the deal with Roma and their manager Eusebio Di Francesco.
Due to China’s 100% tax on transfer fees, it is believed Guangzhou are seeking an initial loan deal, with an obligation to purchase next summer. Nainggolan meanwhile could earn up to €12m a year (£205,000 a week).